Injection Training Video. December 2021. Pick, pull, place, and press. COSENTYX [prescribing information]. VIDEO:Patient points to needle guard on syringe. Now Ill take you through the process step by step. By selecting "Yes" below, you certify that you are a Healthcare Professional and that you wish to proceed to the Healthcare Professionals Only section on the AbbVie Medical Information site. have recently received or are scheduled to receive an immunization (vaccine). 1. Plaque Psoriasis: SKYRIZI is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. Both Skyrizi and Stelara have a number of possible side effects, some of which can be serious. RISANKIZUMAB 75mg in 0.83mL; ISOPROPYL ALCOHOL 0.70mL in 1mL. This is normal. While these factors are important, there are additional considerations for selecting a treatment. Serious hypersensitivity reactions, including anaphylaxis, have been reported with the use of SKYRIZI. They are trained to direct patients to their HCP for treatment-related advice, including further referrals. AUDIO:And safely discard the used Pen. Ryan C, Crowley J, Valdecantos WC, Wu T, Reich K. Efficacy of switching to risankizumab compared with continued adalimumab treatment in patients with moderate-to-severe plaque psoriasis. US-SKZG-210051 Is Skyrizi approved for treating psoriatic arthritis? The SKYRIZI Instructions for Use contains more detailed instructions on the preparation and administration of SKYRIZI [see Instructions for Use]. Products or treatments described on this site are available in the U.S. but may not be available in all other countries. See "What is the most important information I should know about SKYRIZI?". . The U.S. Food and Drug Administration (FDA) approved SKYRIZI as a single 150mg dose based on three clinical trials which demonstrated that it was bioequivalent, meaning it worked the same as two 75 mg doses. Subsequently, the diluted SKYRIZI solution can be stored (protected from direct and indirect sunlight) for 8 hours at room temperature at up to 77F (25C) after dilution (cumulative time after preparation including the storage and the infusion period). See how that works? Drug class: Interleukin inhibitors. DO NOT use if the liquid is cloudy or contains flakes or large particles. SKYRIZI may cause serious side effects. SUPER:Do notrub the injection site. Can you drink alcohol while taking Skyrizi? Watch it and also read the entire SKYRIZI Instructions for Use leaflet, inserted with your medication package. 1. But this video will be helpful. Evaluate patients for tuberculosis infection prior to initiating treatment with SKYRIZI. SKYRIZI (risankizumab-rzaa) is now available in the U.S. as a single dose injection for the treatment of adults with moderate-to-severe plaque psoriasis. Do notuse SKYRIZI if liquid has beenfrozeneven if it has been thawed. AbbVie is providing these links to you only as a convenience and the inclusion of any link does not imply the endorsement of the linked site by AbbVie. moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy). Plaque Psoriasis: SKYRIZI is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy. AUDIO:Now, Ive done this a few times by myself, but my doctor originally walked me through how to inject, and I called Bryan, whos my Nurse Ambassador, when I first started injecting on my own at home. Hepatotoxicity in Treatment of Crohns Disease. The usual dosage is 150mg every 12 weeks consisting of two 75mg subcutaneous injections and people can be taught how to self-administer. Pick the injection siteyour left or right thigh or your stomach. Do not shake the vial or diluted solution in the infusion bag or glass bottle. Jason: In summary, I can communicate to my patients that SKYRIZI is proven to deliver high levels of skin clearance, including results as early as 4 weeks. On January 21, 2022, the SKYRIZI (risankizumab-rzaa) Prescribing Information and Medication Guide were updated to include new information about serious allergic reactions. The most common side effects of SKYRIZI in people treated for plaque psoriasis and psoriatic arthritis include: upper respiratory infections, headache, feeling tired, injection site reactions, and fungal skin infections. US-SKZ-220500 Instruct the patient to read the Instructions for Use before administration. If a dose is missed, administer the dose as soon as possible. Limitations may apply. By selecting "Continue" below, you certify that you are a Healthcare Professional and that you wish to proceed to the Healthcare Professionals Only section on the AbbVie Medical Information site. AUDIO:There safe and sound, and also out of reach. Each dose consists of one The recommended dosage is 150 mg administered by subcutaneous injection at Week 0, Week 4, and every 12 weeks thereafter. Generic name: RISANKIZUMAB 75mg in 0.83mL; ISOPROPYL ALCOHOL 0.70mL in 1mL It is normal to see 1 or more bubbles in the window. Your healthcare provider should watch you closely for signs and symptoms of TB during and after treatment with SKYRIZI. Do not use SKYRIZI if you are allergic to risankizumab-rzaa or any of the ingredients in SKYRIZI. Following the starter doses, it can be administered via 1 prefilled pen or syringe. Skyrizi (risankizumab-rzaa) is a prescription biologic drug that is used to manage the symptoms of plaque psoriasis in adults. SKYRIZI maintains a dosing regimen for PsA that is consistent with the existing regimen for patients with moderate to severe plaque psoriasis - a single 150 mg subcutaneous injection four times a year (after two starter doses at weeks 0 and 4) - and can be administered alone or in combination with DMARDs.1 "In the pivotal KEEPsAKE trials . You can take Skyrizi or Humira if your plaque psoriasis could benefit from phototherapy (light treatment) or systemic therapy (drugs that work throughout your body). These doses are used to get increased levels of the drug into your body. You are about to enter a site that is for US healthcare professionals only. If a patient develops such an infection or is not responding to standard therapy, closely monitor and discontinue SKYRIZI until the infection resolves. AbbVie is not responsible for the contents of any such site or any further links from such site. Im going to show you how to do thatstep by step, and address any questions you may have. Skyrizi, a drug used to treat plaque psoriasis, can cause certain side effects. Conversely, the presence of this link does not imply the linked site's endorsement of SKYRIZI.com or AbbVie. Medications that interact with the immune system may increase your risk of getting an infection after receiving live vaccines. Dont inject through clothes, or into skin that doesnt look normal. Jason: It can be difficult at times for patients to understand PASI 90 data. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. You can see them right here on the package. AUDIO:Now, it seemed tricky at first, but I got it down soon enough. Also, there is no routine monitoring after an initial TB test. Recommended Dosage for Psoriatic Arthritis. Okay. It can be taken in your doctor's office or at home after you receive training from your healthcare provider. 6. VIDEO:Patient holds syringe with needle pointing down, removes cap to check liquid, shows to camera. With SKYRIZI, warnings and precautions include risk of infections, tuberculosis, and avoiding the use of live vaccines. We use cookies to offer you a better experience and analyze our site traffic. SKYRIZI [package insert]. AUDIO:Now I can see the green activator button and inspection window. Visit. SKYRIZI 150 mg/mL and 360 mg/2.4 mL: a colorless to yellow, and clear to slightly opalescent solution. Conversely, the presence of this link does not imply the linked site's endorsement of SKYRIZI or AbbVie. If youve done this before, great! The following information on important labeling revisions does not include all changes; please refer to the SKYRIZI Full Prescribing Information. have TB or have been in close contact with someone with TB. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The most common side effects of SKYRIZI in people treated for Crohns disease include: upper respiratory infections, headache, joint pain, stomach (abdominal) pain, injection site reactions, low red blood cells (anemia), fever, back pain, and urinary tract infection. SKYRIZI Dosing 4 doses a yearafter 2 starter doses With SKYRIZI, quarterly dosing can fit into your schedule. See the Medication Guide or Consumer Brief Summary for a complete list of ingredients. AUDIO:And thats it! On August 9, 2021, AbbVie announced that SKYRIZI (risankizumab-rzaa), an interleukin-23 inhibitor, is now available in the U.S. as a single dose injection for the treatment of adults with moderate-to-severe plaque psoriasis. Your healthcare provider should check you for infections and tuberculosis (TB) before starting treatment with SKYRIZI and may treat you for TB before you begin treatment with SKYRIZI if you have a history of TB or have active TB. You are leaving the SKYRIZI (risankizumab-rzaa) site and connecting to a site that is not under the control of AbbVie. SUPER:This demonstration is a guide to injecting with the SKYRIZI prefilled syringe. REFERENCE: 1. Should such an infection occur, discontinue SKYRIZI until infection resolves. have recently received or are scheduled to receive an immunization (vaccine). What it isnt. Here, you can see rapid skin clearance on an actual patient from the UltlMMa-2 trial. Most common (1%) adverse reactions associated with SKYRIZI in plaque psoriasis and psoriatic arthritis include upper respiratory infections, headache, fatigue, injection site reactions, and tinea infections. You may have slight bleeding. 2 starter doses4 weeks apart Continue with 1 dose every 12 weeks Choose what's right for you SKYRIZI is available as the SKYRIZI Pen or pre-filled syringe. 5. Youve got this. The recommended dose is 150mg. SKYRIZI [package insert]. Do not inject into the same site. Conversely, the presence of this link does not imply the linked site's endorsement of SKYRIZIHCP.com or AbbVie. PsA dosing: With a loading dosage: 150 mg at Weeks 0, 1, 2, 3, and 4 and every 4 weeks thereafter. AUDIO:So, first, I pick my injection site. Monitor patients for signs and symptoms of active TB during and after SKYRIZI treatment. I am a licensed Healthcare Professional and wish to proceed to the Healthcare Professionals Only AbbVie Medical Information Site. Then, the recommended maintenance dosage is 360 mg given by subcutaneous (under the skin) injection at Week 12, and then every 8 weeks, thereafter. Skyrizi Dosage Take this medication exactly as prescibed by your doctor. It is also used to. treat adults: with moderate to severe plaque psoriasis who may benefit from taking injections or pills (systemic therapy) or treatment using ultraviolet or UV light (phototherapy). If not used immediately, store the diluted SKYRIZI solution refrigerated and protected from light for up to 20 hours between 36F to 46F (2C to 8C). If a serious hypersensitivity reaction occurs, discontinue SKYRIZI and initiate appropriate therapy immediately. SUPER:Do notwarm SKYRIZI in any other way (for example,do notwarm it in the microwave or in hot water). They will get to know you and help you start and stay on track with your treatment plan. In 1 year, after just 5 doses, 58% of SKYRIZl-treated patients achieved PASI 100. Here it is. However, from 9th July 2021 each injection will now contain the full dose (150mg) and so only one injection will be required each time. The active comparator (ustekinumab) used for these studies was sourced from the European Union. 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