novartis acquires avexis

AVXS-101 uses REGENXBIO's NAV AAV9 vector. Traducciones en contexto de "Drugmaker Novartis'" en ingls-espaol de Reverso Context: Drugmaker Novartis' sales in the fourth-quarter rose by 18%, but the Swiss company's earnings. Basel, April 9, 2018-Novartis announced today that it has entered into an agreement and plan of merger with AveXis, Inc. to acquire the US-based Nasdaq-listed clinical stage gene therapy company for USD 218 per share or a total of USD 8.7 billion in cash. the importance of closing certainty to the Board and various regulatory considerations relevant to a potential acquisition of the Company by Novartis. Last week, Novartis ( NVS 1.03%) paid up almost $10 billion for AveXis . The tender offer for the outstanding shares of common stock, par value USD 0.0001, of AveXis, Inc. (the "Company") described in this press release has not commenced. Until the acquisition is completed, both AveXis and Novartis must continue to operate as independent entities and carry on their respective businesses as usual. We would gain with the team at AveXis another gene therapy platform, in addition to our CAR-T platform for cancer, to advance a growing pipeline of gene therapies across therapeutic areas. 09, 2018 11:49 AM . In addition to developing Zolgensma to treat SMA, AveXis also plans to develop other novel treatments for rare neurological diseases, including Rett syndrome and a genetic form of amyotrophic lateral sclerosis caused by mutations in the superoxide dismutase 1 (SOD1) gene. 'The Bridge(s) across the Saar river') is the capital and largest city of the state of Saarland, Germany.Saarbrcken is Saarland's administrative, commercial and cultural centre and is next to . At the time the tender offer is commenced, Novartis and an indirect wholly-owned subsidiary of Novartis ("Purchaser") will file, or will cause to be filed, a Schedule TO Tender Offer Statement with the U.S. Securities and Exchange Commission (the "SEC") and the Company will file a Schedule 14D-9 Solicitation/Recommendation Statement with the SEC, in each case with respect to the tender offer. AveXis (AVXS) announced that it has entered into an agreement and plan of merger with Novartis (NVS) pursuant to which Novartis will acquire AveXis for $218 per share or a total of $8.7B in cash. On April 17, 2018, Purchaser and Novartis filed a Tender Offer Statement on Schedule TO with the SEC and AveXis filed a Schedule 14D-9 with the SEC, in each case with respect to the Offer. Novartis. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise. Dyal Co LLC acted as the financial adviser of Novartis, while Goldman Sachs advised AveXis. About NovartisNovartis is reimagining medicine to improve and extend people's lives. It is estimated that one out of every 6,000-10,000 children born is affected by some form of SMA. DisclaimerThis press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995. The issue predated AveXis' acquisition by Novartis in April 2018, for $8.7 billion. About 130,000 people of nearly 150 nationalities work at Novartis around the world. Such forward looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. Those programs existed as part of the acquisition of AveXis. The transaction was unanimously approved by the Boards of both companies. We relish the opportunity to leverage our expertise, our 70-plus year heritage in neuroscience and our global footprint to help AVXS-101 benefit high-need SMA patients around the world.". Novartis will pay $218 per share, which is a 72 percent premium over AveXis's 30-day volume-weighted average stock price. ZURICH (Reuters) - Swiss drugmaker Novartis NOVN.S is moving further into gene therapy by buying AveXis AVXS.O for $8.7 billion, adding a rare-disease treatment that could reap billions in. The deal is expected to close in mid-2018. Such forward-looking statements are based on our current beliefs and expectations regarding future events, and are subject to significant known and unknown risks and uncertainties. The actual results or developments anticipated may not be realized or, even if substantially realized, they may not have the expected consequences to or effects on REGENXBIO or its businesses or operations. The US Food and Drug Administration (FDA) has granted AVXS-101 Orphan Drug designation for the treatment of SMA as well as Breakthrough Therapy designation for SMA Type 1. EUROGRAPHICS 2023, the 44th Annual Conference of the European Association for Computer Graphics, will take place on May 8 - 12, 2023.It is organized by the Saarland Informatics Campus (SIC) in Saarbrcken, Germany. REGENXBIO and its third-party NAV Technology Platform Licensees are applying the NAV Technology Platform in the development of a broad pipeline of candidates in multiple therapeutic areas. Saarbrcken (German pronunciation: [zabk] (); French: Sarrebruck; Rhine Franconian: Saarbrigge [zab]; Luxembourgish: Saarbrcken [zabekn]; Latin: Saravipons, lit. Novartis has announced that it has entered into an agreement to acquire the Illinois-based clinical stage gene therapy company AveXis, Inc. for $218 per share or a total of $8.7 billion in cash. Novartis is on Twitter. "We believe this expanded partnership with REGENXBIO, which provides exclusive rights to the entire REGENXBIO NAV Technology Platform, will further strengthen our leadership position in gene therapy treatments for this devastating disease.". The addition of the six-building Longmont campus consists of nearly 700,000 square-feet of space for biologic drug manufacturing, offices, laboratories, warehousing and utilities. | TradeStation CHICAGO, May 01, 2018 (GLOBE NEWSWIRE) -- AveXis, Inc. (NASDAQ:AVXS), a clinical-stage gene therapy company developing treatments for patients suffering from rare and life-threatening neurological genetic diseases, today announced that the required waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 applicable to the proposed acquisition of AveXis by Novartis AG . About ZolgensmaZolgensma (onasemnogene abeparvovec-xioi; AVXS-101) is an investigational gene therapy currently in development as a one-time infusion for SMA Type 1. Apr. India | ENG . Basel, May 1, 2018 - Novartis AG (NYSE: NVS) ("Novartis") today announced that the required waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 (the "HSR Act") applicable to Novartis' cash tender offer for AveXis, Inc. (NASDAQ: AVXS) ("AveXis") has expired. The acquisition would also accelerate our strategy to pursue high-efficacy, first-in-class therapies and broaden our leadership in neuroscience. Last week, Novartis (NYSE: NVS) paid up almost $10 billion for AveXis -- an 88% premium over the gene therapy company's previous close. AveXis was acquired by Novartis in 2018 for USD 8.7 billion. Novartis has leading positions globally in each of these areas. Since then, we started partnering with [the Novartis Institutes of Biomedical Research] to apply this platform to different diseases. View Lance Meitz's business profile as Research Associate III, Analytical Development-Bioassay at Novartis Gene Therapies. Disclaimer This press release contains forward-looking statements that can generally be identified by words such as "will," or similar expressions. Swiss-based Novartis has struck a deal to acquire Bannockburn, Illinois-based AveXis for $8.7 billion. AveXis, Inc. 2275 Half Day Rd, Suite 200 Bannockburn, Illinois 60015 (847) 572-8280 . Novartis products are sold in approximately 155 countries around the world. For more information, please visit http://www.novartis.com. The incidence of SMA is approximately one in 10,000 live births. The company also intends to expand the study of gene therapy into two additional rare neurological monogenic disorders: Rett syndrome (RTT) and a genetic form of amyotrophic lateral sclerosis (ALS) caused by mutations in the superoxide dismutase 1 (SOD1) gene. The transaction was unanimously approved by the Boards of both companies. Novartis said on Monday it plans to buy AveXis for $218 per share in a cash deal totaling $8.7 billion, adding a therapy hopeful for spinal muscular atrophy (SMA) to the Swiss drugmaker's pipeline. DisclaimerThis press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995 that can generally be identified by words such as "proposed," "tender offer," "commenced," "subject to," "scheduled," "unless," "offer," "conditions," or similar expressions, or by express or implied discussions regarding the potential outcome of the acquisition of AveXis by Novartis. AstraZeneca fronts $30 million upfront for NASH licensing deal with Ionis Pharmaceuticals. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements as a result of new information, future events or otherwise. We should find out soon if that confidence is well placed, because in announcing its acquisition of AveXis, Novartis said it wants to file for a Food and Drug Administration OK later this year. Facility to become the largest of four state-of-the-art sites involved in manufacturing of AveXis gene therapies for pipeline of rare genetic diseases including spinal muscular atrophy. Basel, April 1, 2019 -- AveXis, a Novartis company, today announced it signed an agreement to purchase an advanced biologics therapy manufacturing campus in Longmont, Colorado, further expanding AveXis' production capacity as it prepares to launch Zolgensma (onasemnogene abeparvovec-xioi[1]) an investigational gene therapy awaiting global regulatory approvals for the treatment of spinal muscular atrophy (SMA) Type 1 and for future gene therapy treatments in development. 19/01/06 08:01 CET The most severe form of SMA is Type 1, a lethal genetic disorder characterized by rapid motor neuron loss and associated muscle deterioration, which results in mortality or the need for permanent ventilation support by 24 months of age for more than 90 percent of patients. "AveXis has now established leading technical manufacturing capabilities with the capacity to deliver our robust pipeline, as well as the flexibility to enter into multiple external partnerships as the development and manufacturing partner of choice in gene therapy.". Novartis' $9.8 billion acquisition of AveXis signals some pretty exciting long-term focus in promising gene therapies. It could spur interest and investment in Chicago's biotech startup mix. As a leading global medicines company, we use innovative science and digital technologies to create transformative treatments in areas of great medical need. AveXis undertakes no obligation, and specifically declines any obligation, to publicly update or revise any such forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law. About EUROGRAPHICS 2023. CHICAGO, April 09, 2018 (GLOBE NEWSWIRE) -- AveXis, Inc. (NASDAQ:AVXS) announced today that it has entered into an agreement and plan of merger with Novartis pursuant to which Novartis will. - of the proceeds from the aforementioned GlaxoSmithKline deal to acquire Avexis for $218 per share or $8.7 billion in total, gaining the lead compound AVXS-101. Disclaimer This press release contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995, that can generally be identified by words such as "to acquire," "to transform," "candidate," "potential," "Breakthrough Therapy Designation," "PRIME designation," "Sakigake," "expected," "offers," "to accelerate," "future," "ongoing," "would," "potentially," "believe," "can," "hopefully," "excited," "pipeline," "Orphan Drug Designation," "would," "ambition," "priorities," "to strengthen," "opportunity," "pending," "will," "expects," "subject to," "planned," or similar expressions, or by express or implied discussions regarding the potential outcome of the tender offer for the shares of AveXis Inc. to be commenced by Novartis, and the potential impact on Novartis of the proposed acquisition, including express or implied discussions regarding potential future sales or earnings of Novartis, and any potential strategic benefits, synergies or opportunities expected as a result of the proposed acquisition; and regarding potential marketing approvals, new indications or labeling for the potential, investigational or approved products described in this press release, or regarding potential future revenues from such products. Novartis Media RelationsE-mail: [emailprotected], Novartis Investor RelationsCentral investor relations line: +41 61 324 7944E-mail: [emailprotected], This site is intended for a global audience, AveXis expands world-leading gene therapy manufacturing capacity with purchase of advanced biologics therapy manufacturing campus in Longmont, Colorado, Diversity & Inclusion Governance and Community, Novartis Commitment to Patients and Caregivers, Novartis Gene Therapies Managed Access Program, Healthcare Professional Resources by Country, Novartis Institutes for BioMedical Research, Cardiovascular and metabolic disease research at Novartis, Autoimmunity, transplantation and inflammatory disease research at Novartis, Musculoskeletal Disease Research at Novartis, DAx: exploratory disease research at Novartis, Community Exploration & Learning Lab (CELL). The first one we announced is a project for Friedreich's ataxia, a muscle-wasting disease. Novartis will pay $218 per share, which is a 72 percent premium over AveXis's 30-day volume-weighted average stock price. You should not place undue reliance on these statements. Zolgensma is designed to address the monogenic root cause of SMA and prevent further muscle degeneration. Such forward-looking statements are based on current expectations and involve inherent risks and uncertainties, including factors that could delay, divert or change any of them, and could cause actual results to differ materially from those projected in its forward-looking statements. About NovartisNovartis provides innovative healthcare solutions that address the evolving needs of patients and societies. Novartis acquires AveXis for $8.7 billion. There can be no guarantee that the proposed acquisition described in this press release will be completed, or that it will be completed as currently proposed, or at any particular time. Neither can there be any guarantee that such products will be commercially successful in the future. ", Paul Hudson, CEO, Novartis Pharmaceuticals said: "Novartis and Avexis bring truly complementary capabilities behind a shared purpose - transforming the care of patients with life-threatening neurological genetic diseases. Sign up to follow @Novartis at http://twitter.com/novartisFor Novartis multimedia content, please visit www.novartis.com/news/media-libraryFor questions about the site or required registration, please contact [emailprotected], Novartis Media RelationsCentral media line: +41 61 324 2200E-mail: [emailprotected], Eric AlthoffNovartis Global External Communications+41 61 324 7999 (office)+41 79 593 4202 (mobile)[emailprotected], Novartis Investor RelationsCentral investor relations line: +41 61 324 7944E-mail: [emailprotected], This site is intended for a global audience, Novartis provides update on proposed acquisition of AveXis, Diversity & Inclusion Governance and Community, Novartis Commitment to Patients and Caregivers, Novartis Gene Therapies Managed Access Program, Healthcare Professional Resources by Country, Novartis Institutes for BioMedical Research, Cardiovascular and metabolic disease research at Novartis, Autoimmunity, transplantation and inflammatory disease research at Novartis, Musculoskeletal Disease Research at Novartis, DAx: exploratory disease research at Novartis, Community Exploration & Learning Lab (CELL), https://www.novartis.com/investors/financial-data/sec-filings, http://investors.avexis.com/phoenix.zhtml?c=254285&p=irol-IRHome. The lead AveXis gene therapy candidate, AVXS-101, has highly compelling clinical data in treating SMA Type 1, which is the number one genetic cause of death in infants, where 9 out of 10 infants do not live to their second birthday or are permanently ventilator dependent. The Rett program, AVXS-201, continues full steam ahead. Novartis Acquisition of AveXis As per the latest pharma acquisition news, Novartis has agreed to pay $218 for each of the AveXis shares. The incidence of SMA is approximately one in 10,000 live births and is the leading genetic cause of infant mortality. "An expanded relationship further aligns REGENXBIO with AveXis in their commitment to develop and commercialize novel gene therapy treatments for SMA, and serves as additional validation of our NAV Technology Platform and its potential utility in this therapeutic area," said Kenneth T. Mills, President and Chief Executive Officer of REGENXBIO. In 2019, Ave Xis 's first gene therapy drug onasemnogene. Talent Acquisition Partner - Contractor Opportunity Temporary, Full Time HR NBS : USA : East Hanover, NJ : Nov 01, 2022: Payroll Services Senior Expert (with Romanian) Regular, Full Time HR NBS : Czech Republic : For additional roles with Novartis Gene Therapies (formerly AveXis) . The Tender Offer Statement (including the Offer to Purchase, the related Letter of Transmittal and other offer documents) and the Solicitation/Recommendation Statement contain important information that should be read carefully before any decision is made with respect to the Offer. Building on the success of Zolgensma (onasemnogene abeparvovec), Novartis Gene Therapies will be responsible for the research, development, manufacturing and commercialization of the next wave of AAV-based innovative gene therapies. "Our Longmont, Colorado, campus, along with our existing manufacturing sites in Illinois, California and North Carolina, will play a crucial role in helping us achieve the future manufacturing capacity required to meet the global patient need for novel gene therapies," said Andrew Knudten, Senior Vice President, Global Strategic Operations. Under the terms of the amendment, REGENXBIO granted AveXis exclusive, worldwide rights to all vectors in REGENXBIO's NAV Technology Platform for the treatment of SMA in addition to adding and amending certain terms of the 2014 License Agreement, including the modification of the assignment provision to now permit assignment in the event of a change of control by AveXis without REGENXBIO's consent. 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