Initial U.S. Approval: 2022. Approval History FDA approved 2022 <1 year. mavacamten. mavacamten. methylene blue. Avoid or Use Alternate Drug. metoprolol, mavacamten. Contraindicated (2) eliglustat. nadolol. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. PRINCETON, N.J.--(BUSINESS WIRE)-- Bristol-Myers Squibb (NYSE: BMY) today announced that the U.S. Food and Drug Administration (FDA) has accepted its supplemental new drug application (sNDA) for CAMZYOS (mavacamten) for an expanded indication to reduce the need for septal reduction therapy (SRT).CAMYZOS is currently FDA approved for the treatment mavacamten. fluconazole and pentamidine both increase QTc interval. Contraindicated. NEW YORK--(BUSINESS WIRE)-- Bristol Myers Squibb (NYSE:BMY) today reports results for the third quarter of 2022, which reflect strong in-line and new product portfolio growth.Our strong results reflect growth of our in-line and new product portfolios, said Giovanni Caforio, M.D., board chair and chief executive officer, Bristol Myers Squibb.. Our teams Contraindicated. Mavacamten may decrease systemic exposures of ethinyl estradiol and progestin, which may lead to contraceptive failure or an increase in breakthrough bleeding. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. fluconazole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. metoprolol and nadolol both increase anti-hypertensive channel blocking. mavacamten. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. mavacamten. fluoxetine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Mavacamten a,b. Either increases effects of the other by pharmacodynamic synergism. oxcarbazepine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. diazepam and melatonin both increase sedation. Contraindicated. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. mavacamten. diltiazem, metoprolol. Generic Name Propranolol DrugBank Accession Number DB00571 Background. Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. NEW YORK, October 25, 2022--(BUSINESS WIRE)--Bristol Myers Squibb (NYSE:BMY) today reports results for the third quarter of 2022, which reflect strong in-line and new product portfolio growth. Serious - Use Alternative (17) carbamazepine mavacamten. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. diltiazem, mavacamten. bisoprolol, mavacamten. mavacamten. 8,9,10 Propranolol was granted FDA 1,9 Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the Avoid or Use Alternate Drug. metoprolol. MODAFINIL - ORAL (moe-DAF-i-nil) COMMON BRAND NAME(S): Provigil USES: Modafinil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. metoprolol. propofol will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Aripiprazole is an atypical antipsychotic orally indicated for treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's Label.It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania Label. metoprolol and propranolol both increase anti-hypertensive channel blocking. Either increases effects of the other by pharmacodynamic synergism. metformin. Avoid or Use Alternate Drug. Use Caution/Monitor. mavacamten. The .gov means it's official. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. Generic Name Osimertinib DrugBank Accession Number DB09330 Background. Generic Name Aripiprazole DrugBank Accession Number DB01238 Background. mavacamten. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. pantoprazole will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. 7,19 Traces of radiolabeled unchanged drug were found in the urine and about 5% of the administered drug was Contraindicated. Serious - Use Alternative (33) abametapir mebendazole. atenolol, mavacamten. A full FDA approval is expected by April 2022 (see Table 5 for other candidates up for approval in 2022). Generic Name Nifedipine DrugBank Accession Number DB01115 Background. mavacamten. bisoprolol and metoprolol both increase anti-hypertensive channel blocking. Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to nicardipine. verapamil, mavacamten. August 2022: Collaboration with GentiBio to develop engineered Treg therapies for inflammatory bowel diseases. mavacamten. intercurrent illness CAMZYOS can causeheart failure due to systolic dysfunction. azelastine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Either increases toxicity of the other by unspecified interaction mechanism. Patient Education modafinil oral. Either increases effects of the other by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. ranolazine, mavacamten. mavacamten. WARNING: RISK OF HEART FAILURE. Generic Name Naloxone DrugBank Accession Number DB01183 Background. cimetidine increases levels of mebendazole by decreasing metabolism. loratadine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. 3 More specifically, naloxone has a high affinity for -opioid receptors, where it acts as an inverse 3 More specifically, naloxone has a high affinity for -opioid receptors, where it acts as an inverse verapamil, metoprolol. metoprolol. methimazole increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism. Before sharing sensitive information, make sure you're on a federal government site. metoprolol. Either increases effects of the other by pharmacodynamic synergism. User Reviews & Ratings. It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a 9 Propranolol is used to treat a number of conditions but most commonly is used for hypertension. cimetidine will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. (5.1) Echocardiogram assessments of left ventricular ejection fraction Hydroxylated metabolite, Doxazosin; Route of elimination. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. mavacamten. Includes Camzyos side effects, interactions and indications. Camzyos (mavacamten) is used for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy. melatonin. ranolazine will increase the level or effect of metformin by decreasing elimination. Generic Name Prochlorperazine DrugBank Accession Number DB00433 Background. Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. Avoid or Use Alternate Drug. Analysts forecast elasomeran sales of over $17 billion in 2021. Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management of psychotic disorders such as generalized non-psychotic anxiety and In a pharmacokinetic study using a 1 mg IV radiolabeled dose and a 2 mg oral dose, 63% of the ingested doxazosin was found to be excreted in the feces and about 9% of the dose was found to be excreted in the urine. Contraindicated. Either increases effects of the other by pharmacodynamic synergism. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: cilostazol, clopidogrel, mavacamten, methotrexate (especially high-dose treatment), rifampin, St John's wort.Some products need stomach acid so that the body can absorb them properly. See full prescribing information for complete boxed warning. Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. mavacamten. mefloquine Generic Name Naloxone DrugBank Accession Number DB01183 Background. Federal government websites often end in .gov or .mil. mavacamten. If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6 inhibitors are given CAMZYOSTM (mavacamten) capsules for oral use . propranolol, mavacamten. valproic acid will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. Tecvayli: teclistamab-cqyv: 10/25/2022: mavacamten: 4/28/2022: To treat certain classes of obstructive hypertrophic cardiomyopathy: 11. metoprolol. losartan will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. telmisartan will increase the level or effect of mavacamten by affecting hepatic enzyme CYP2C19 metabolism. August 2022: Collaboration with GentiBio to develop engineered Treg therapies for inflammatory bowel diseases. atenolol and metoprolol both increase anti-hypertensive channel blocking. Expect additive negative inotropic effects of mavacamten and other drugs that reduce cardiac contractility. Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. 3,10,11,13 Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972. Review this Drug No reviews. Strong or moderate CYP2C19 inhibitors may increase mavacamten systemic exposure, resulting in heart failure due to systolic dysfunction. methylene blue and fluoxetine both increase serotonin levels. Bristol Myers Squibb Announces Change to Earnings Conference Call Dial-In Information for Third Quarter 2022 Results Scheduled for October 26, 2022 09/16/2022 Bristol Myers Squibb Receives European Commission Approval for LAG-3-Blocking Antibody Combination, Opdualag (nivolumab and relatlimab), for the Treatment of Unresectable or Approval Date FDA-approved use on approval date* 28. Avoid or Use Alternate Drug. doxycycline will increase the level or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. mavacamten. pentamidine.
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